Gold nanoparticle (AuNP)-mediated photothermal therapy represents an alternative to the effective ablation of cancer cells. However, the photothermal response of AuNPs must be tailored to improve the therapeutic efficacy of plasmonic photothermal therapy (PPT) and mitigate its side effects.
Various gold nanoplatforms including nanospheres, nanoshells, nanorods, nanocages and nanostars have been used for effective photothermal treatment of various cancers. GNPs have also been used in immunotherapies, involving cancer antigen and immune adjuvant delivery as well as combination therapies with photothermal therapy.
02.05.2018· Gold nanoparticles (GNPs) can play a significant role in this regard since GNPs can be used as radiation dose enhancers and anticancer drug carriers. Anticancer drug, bleomycin, was chosen as the model drug, since it could be easily conjugated onto GNPs through the gold–thiol bond.
Gold Nanoparticle Mediated Multi-Modal CT Imaging of Hsp70 Membrane-Positive Tumors by Melanie A. Kimm 1, Maxim Shevtsov 2,3,4, Caroline Werner 2, Wolfgang Sievert 2, Wu Zhiyuan 2, Oliver Schoppe 2,5, Bjoern H. Menze 2,5, Ernst J. Rummeny 1, Roland Proksa 6, Olga Bystrova 4, Marina Martynova 4, Gabriele Multhoff 2 and Stefan Stangl 2,* 1
Central to the concept of seed-mediated growth of nanoparticles is that small nanoparticle seeds serve as nucleation centers to grow nanoparticles to a desired size. We have examined this common assumption in a model system, the wet stone synthesis of gold nanoparticles via reduction of a gold salt, by transmission electron microscopy and electronic absorption spectroscopy. We find that
Laser-induced photoporation, especially in combination with gold nanoparticles, is an alternative physical method that is receiving increasing attention for delivering macromolecules in cells. By allowing gold nanoparticles to bind to the cell membrane, nanosized membrane pores can be created upon pulsed laser illumination.
To achieve this objective, gold nanoparticles (AuNPs) having peroxidase-like activity and capability of promoting silver deposition were used as the versatile label for
However, the size limitation of approximately 100 nm in classic DNA origami hampers its plasmonic applications. Herein, we report a jigsaw‐puzzle‐like assembly strategy mediated by gold nanoparticles (AuNPs) to break the size limitation of DNA origami.
The gold nanoparticle-mediated (GNOME) laser perforation (GNOME-LP) technology was developed to achieve a gentle cell permeabilization allowing the entry of small molecule into cells while...
A promising therapeutic platform for cancer is offered by nanoparticle-mediated therapy. This review highlights the development and applications of various nanoparticle platforms for photo-induced hyperthermia and immunotherapy. Taking advantage of gold's high biocompatibility, gold nanoparticles (GNPs) can be injected intravenously and accumulate preferentially in cancer cells due to the
Gold Nanoparticle Mediated Multi-Modal CT Imaging of Hsp70 Membrane-Positive Tumors . by Melanie A. Kimm 1, Maxim Shevtsov 2,3,4, Caroline Werner 2, Wolfgang Sievert 2, Wu Zhiyuan 2, Oliver Schoppe 2,5, Bjoern H. Menze 2,5, Ernst J. Rummeny 1, Roland Proksa 6, Olga Bystrova 4, Marina Martynova 4, Gabriele Multhoff 2 and Stefan Stangl 2,* 1. Department of Diagnostic and Interventional
Gold nanoparticle mediated cancer immunotherapy Nanomedicine. 2014 Apr;10(3):503-14. doi: 10.1016/j.nano.2013.09.011. Epub 2013 Oct 5. Authors Joao Paulo Mattos Almeida 1,Elizabeth Raquel Figueroa 1,Rebekah Anna Drezek 2 Affiliations 1 Department of
03.12.2019· Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017;9(4):e1449. Article CAS Google Scholar 20. Borran AA, Aghanejad A, Farajollahi A, Barar J, Omidi Y. Gold nanoparticles for radiosensitizing and imaging of cancer cells. Radiat Phys Chem. 2018;152:137–44. CAS Article
gold nanoparticles alone can generate singlet oxygen [ ]. So combination of GNPs-mediated photothermal therapy (PTT)andphotosensitizers-mediatedphotodynamictherapy (PDT) was reported to achieve synergistic PTT and PDT e ects on destroying cancer cells by many groups [,] . e gold nanoparticles can enhance radiosensitivity of cancer cells; this e ect is shown in vivo and in vitro, at
Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment Rachel S. Riley1 and Emily S. Day1,2* Photothermal therapy (PTT), in which nanoparticles embedded within tumors gen-erate heat in response to exogenously applied laser light, has been well documen-ted as an independent strategy for highly selective cancer treatment. Gold-based
Gold Nanoparticle Mediated Multi-Modal CT Imaging of 3 Hsp70 Membrane Positive Tumors Melanie A. Kimm,Maxim Shevtsov,Caroline Werner,Wolfgang Sievert,Zhiyuan Wu,Oliver Schoppe,Bjoern H. Menze,Ernst J. Rummeny,Roland Proksa,Olga Bystrova,Marina Martynova,Gabriele Multhoff *,
Gold nanoparticles (GNPs) and their functional derivatives are of great interest because of their many biomedical applications. GNPs are increasingly being incorporated into new diagnostic and therapeutic approaches in medicine. Consequently, there has been a strong push to fully understand their interactions with blood components. The agglomeration of cells reflects the interaction of
Apigenin mediated gold nanoparticle synthesis and their anti-cancer effect on human epidermoid carcinoma (A431) cells I. Rajendran, H. Dhandapani, R. Anantanarayanan and R. Rajaram, RSC Adv., 2015, 5, 51055 DOI: 10.1039/C5RA04303D If you are not the
Gold‐nanoparticle‐mediated hyperthermia shows particular promise in animal studies, and early clinical testing is currently underway. In this article, the rapidly evolving field of gold nanoparticle thermal therapy is reviewed, highlighting recent literature and describing current challenges to clinical translation of the technology. Citing Literature . Number of times cited according to
Gold nanoparticle mediated cancer immunotherapy Nanomedicine. 2014 Apr;10(3):503-14. doi: 10.1016/j.nano.2013.09.011. Epub 2013 Oct 5. Authors Joao Paulo Mattos Almeida 1,Elizabeth Raquel Figueroa 1,Rebekah Anna Drezek 2 Affiliations 1 Department of
03.12.2019· Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017;9(4):e1449. Article CAS Google Scholar 20. Borran AA, Aghanejad A, Farajollahi A, Barar J, Omidi Y. Gold nanoparticles for radiosensitizing and imaging of cancer cells. Radiat Phys Chem. 2018;152:137–44. CAS Article
Colloidal gold is a sol or colloidal suspension of nanoparticles of gold in a fluid, usually water. The colloid is usually either an intense red colour (for spherical particles less than 100 nm) or blue/purple (for larger spherical particles or nanorods). Due to their optical, electronic, and molecular-recognition properties, gold nanoparticles are the subject of substantial research, with
DOI: 10.4172/2157-7439.1000e125 Corpus ID: 137301791. Gold Nanoparticle Mediated Photo-Chemotherapy @inproceedings{Ramos2012GoldNM, title={Gold Nanoparticle Mediated Photo-Chemotherapy}, author={James Ramos and David Taylor and Kaushal Rege}, year={2012} }
01.01.2017· Gold Nanoparticle Mediated Phototherapy for Cancer. Link/Page Citation 1. Introduction Cancer is one of the main leading causes of death all over the world. Currently the most successful cancer treatment method usually involves intrusive processes including chemotherapy, radiation, and surgery to remove the tumor if possible, followed by more chemotherapy and radiation. Even if the
cancers Article Gold Nanoparticle Mediated Multi-Modal CT Imaging of Hsp70 Membrane-Positive Tumors Melanie A. Kimm 1, Maxim Shevtsov 2,3,4, Caroline Werner 2, Wolfgang Sievert 2, Wu Zhiyuan 2, Oliver Schoppe 2,5, Bjoern H. Menze 2,5, Ernst J. Rummeny 1, Roland Proksa 6, Olga Bystrova 4, Marina Martynova 4, Gabriele Multho 2 and Stefan Stangl 2,* 1 Department of Diagnostic and
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Gold nanoparticles (AuNPs) absorb light and can be used to heat and ablate tumors. The “tissue window” at ∼800 nm (near infrared, NIR) is optimal for best tissue penetration (∼2cm). Previously large, 50-150nm gold nanoshells and nanorods that absorb well in the NIR have been used.
Apigenin mediated gold nanoparticle synthesis and their anti-cancer effect on human epidermoid carcinoma (A431) cells I. Rajendran, H. Dhandapani, R. Anantanarayanan and R. Rajaram, RSC Adv., 2015, 5, 51055 DOI: 10.1039/C5RA04303D If you are not the
16.02.2017· Impressively, researchers have extensively validated gold nanoparticle-mediated photothermal therapy as an independent treatment strategy in pre-clinical studies, and the technology is currently being evaluated in multiple clinical trials. More recently, researchers have begun investigating the use of photothermal therapy in combination with secondary treatment strategies, such as
12.03.2020· Ravindra P 2009 Protein-mediated synthesis of gold nanoparticles Mater. Sci. Eng. B 163 93–8. Crossref Google Scholar. Dykman L A, Khlebtsov N G, Chem R, Dykman L A and Khlebtsov G 2019 Methods for stone synthesis of colloidal gold Methods for stone synthesis of colloidal gold Chem. Rev. 88 229–47. IOPscience Google Scholar. Newman J D S and Blanchard G J 2006 Formation of gold
Gold Nanoparticle Mediated Laser Transfection for Efficient siRNA Mediated Gene Knock Down. Einloggen. Services. English Deutsch. Über das Repositorium Suchen und Entdecken Publizieren. Startseite → Weitere Einrichtungen → An-Institute → Dokumentanzeige
DOI: 10.4172/2157-7439.1000e125 Corpus ID: 137301791. Gold Nanoparticle Mediated Photo-Chemotherapy @inproceedings{Ramos2012GoldNM, title={Gold Nanoparticle Mediated Photo-Chemotherapy}, author={James Ramos and David Taylor and Kaushal Rege}, year={2012} }
01.01.2017· Gold Nanoparticle Mediated Phototherapy for Cancer. Link/Page Citation 1. Introduction Cancer is one of the main leading causes of death all over the world. Currently the most successful cancer treatment method usually involves intrusive processes including chemotherapy, radiation, and surgery to remove the tumor if possible, followed by more chemotherapy and radiation. Even if the
Investigation of biophysical mechanisms in gold nanoparticle mediated laser manipulation of cells using a multimodal holographic and fluorescence imaging setup
These results suggest that magnetic gold nanoparticle mediated siRNA silencing Bag-1 is an effective gene therapy method for colon cancer. Introduction. According to the 2014 cancer statistics from the American Cancer Society, colon cancer is the third cause of human cancer incidence and mortality. A total of 96,830 new colon cancer cases and 50,310 deaths are projected to occur in the US in
Gold nanoparticles serve as conducting nodes and different molecules can bind to the gold nanoparticle using anchoring groups such as thiols or amines . The conductance between neighboring nanoparticles depends on a multitude of factors including the conductivity of surrounding molecules, the type of bond between molecules and nanoparticles and the interparticle distance [3,5,6] .
03.11.2016· Gold nanoshell-mediated laser induced optical breakdown. Gold nanoshell exposed to 70 fs length laser pulse at 800 nm in water. Interaction of the laser light with gold nanoparticle leads to
Nanoparticle-Mediated Drug Delivery for the Treatment of Cardiovascular Diseases Gold nanoparticles act as an excellent payload for imaging and targeted delivery of vascular endothelial growth factors to ischemic muscle tissues in the murine hindlimb ischemic model. Murine model of ischemia is a typical model for peripheral artery disease. Gold nanoparticles of size below 200 nm
Gold nanoparticles that target degraded elastin improve imaging and rupture prediction in an AngII mediated mouse model of abdominal aortic aneurysm . Xiaoying Wang 1, Brooks A Lane 2, John F Eberth 2, Susan M. Lessner 2, Naren R. Vyavahare 1 . 1. Department of Bioengineering, Clemson University 2. Cell Biology & Anatomy, University of South Carolina School of Medicine. This is an
The potency of many biomedical applications of gold nanoparticles (AuNPs); i.e., (i) bioimaging, (ii) diagnostic, (iii) therapeutic, (iv) drug carriers, and (v) immunochemical properties; are limited due its sensitivity toward salt and pH allowing variation in nanogeometry during practical applications. Such limitations directed the synthesis of AuNPs having extreme salt and pH resistant